Neuromelanin marks the spot: identifying a locus coeruleus biomarker of cognitive reserve in healthy aging
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منابع مشابه
Neuromelanin marks the spot: identifying a locus coeruleus biomarker of cognitive reserve in healthy aging.
Leading a mentally stimulating life may build up a reserve of neural and mental resources that preserve cognitive abilities in late life. Recent autopsy evidence links neuronal density in the locus coeruleus (LC), the brain's main source of norepinephrine, to slower cognitive decline before death, inspiring the idea that the noradrenergic system is a key component of reserve (Robertson, I. H. 2...
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Many studies point out the existence of individual differences both in the levels of age-related cognitive impairment and in the way this impairment occurs: some people can tolerate brain damage for a longer time without showing external signs of damage. The concept of cognitive reserve emerges as a useful and interesting approach to explain this phenomenon. This paper attempts to describe the ...
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In order to elucidate the chemical structure of black to brown pigments, neuromelanins (NMs), in the substantia nigra (SN) and the locus coeruleus (LC) in the central nervous system of humans and other mammalian species during aging, chemical degradative methods are powerful tools. HPLC analysis after hydroiodic acid hydrolysis detected aminohydroxyphenylethylamines, aminohydroxyphenylacetic ac...
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Cognitive reserve explains why those with higher IQ, education, occupational attainment, or participation in leisure activities evidence less severe clinical or cognitive changes in the presence of age-related or Alzheimer's disease pathology. Specifically, the cognitive reserve hypothesis is that individual differences in how tasks are processed provide reserve against brain pathology. Cogniti...
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Research on cognitive aging has focused on how decline in various cortical and hippocampal regions influence cognition. However, brainstem regions play essential modulatory roles, and new evidence suggests that, among these, the integrity of the locus coeruleus (LC)-norepinephrine (NE) system plays a key role in determining late-life cognitive abilities. The LC is especially vulnerable to toxin...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2016
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2015.09.019